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Dr. Pradeep Das
Scientist G & Director
   
Date of Birth:
03. 08. 1956
Sex: Male
Date of Joining in ICMR: 10.08.1982
Designation: Director
Discipline: Microbiology
Date of Joining in Present Post:
04.05.2005
Office
Rajendra Memorial Research Institute of Medical Sciences
(Indian Council of Medical Research)Department of Health Research, Ministry of Health & Family Welfare, Govt of India, Agamkuan, Patna-800007
Telephone: 0612- 2631565
Fax: 0612-2634379
Residence: Director's Banglow
RMRIMS Campus,
Agamkuan, Patna-800007
Telephone: 0612- 2631565
E-Mail: drpradeep.das@gmail.com
 
Educational Qualifications:
  1. Ph.D.(1978-81), Central Drug Research Institute, Lucknow.
  2. M.Sc.(1975-77), Kanpur University, Kanpur.
 
Research Experience:
 
Post Organization Period
SCIENTIST B


National Institute of Cholera and Enteric Diseases, P-33 CIT Road, Scheme XM, Beliaghata, Kolkata - 700010. 10.08.1982-30.06.1988.
SCIENTIST C

National Institute of Cholera and Enteric Diseases, P-33 CIT Road, Scheme XM, Beliaghata, Kolkata - 700010. 01.07.1988 -30.06.1993.
SCIENTIST D

National Institute of Cholera and Enteric Diseases, P-33 CIT Road, Scheme XM, Beliaghata, Kolkata - 700010. 01.07.1993 –30.06.1998
SCIENTIST E

National Institute of Cholera and Enteric Diseases, P-33 CIT Road, Scheme XM, Beliaghata, Kolkata - 700010. 01.07.1998 –03.05.2005
SCIENTIST G

Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research), Agamkuan, Patna-800007. 04.05.2005 –till date
 
Membership/Fellowship:     
  1. Life Society for Biological Chemists of India (Life Member).
  2. Zoological Society of India (Life Member).
  3. The Indian Society of Parasitology (Life Member).
  4. Indian Immunological Society (Memeber)
  5. Society for Biological Chemists of India (Member)
  6. International Society for Protozoologist (Member)
  7. Society of Parasitologists (Member)
 
Awards: 
  1. Recipient of UNESCO-IUMS-MIRCENS-SGM Award for the year 2000-2001 to work at the Laboratory of Dr. Rodney Adam, Department of Microbiology & Immunology, University of Arizona, Tucson, AZ, USA.

  2. Knoll Gastroenterology Oration Award for the Year 1998.

  3. Awarded CONACYT International Visiting Professorship for the year 1994 –95 to work at CINVESTAV Mexico.

  4. Awarded NIH Fogetty fellowship to carry out the Post-doctoral research at University of Pennsylvania, USA (1986-1988).

  5. Best oral presentation award at the 3rd Asian conference on diarrheal diseases, Bangkok, Thailand (1985).

  6. Awarded CEDA fellowship to carry out training in Gut immune responses in amoebiasis at University of Mac Gill, Mac Donald College, Canada (1981).
 
Foreign Visits:
  1. Delivered a talk on “Studies on Fibrillarin and snRNA interaction during posttranscriptional modification of rRNA in Giardia lamblia” at the “40th Anniversary United States-Japan Cooperative Medical Sciences Program” on December 8th, at Kyoto, Japan.

  2. On invitation delivered a talk on “Molecular mechanisms of pathogenesis in enteric parasites” at the National Institute of Infectious Diseases, Tokyo, Japan on 5th December 2004.

  3. Differential gene expression during human collagen and E.histolytica interaction, at the “EMBO-Workshop on Pathogenesis of Amoebiasis-From Genomics to Diseases” on November 17th and 18th, held at Ein Gedi, Israel

  4. Role of Fibrillarin and snRNA in post-transcriptional modification of rRNA in Giardia lamblia in the “10TH Asian Conference On Diarrhoeal Diseases And Nutrition” held at Dhaka, Bangladesh on December 7 – 9 2003.

  5. S. Sengupta, A. Debnath, S. De and Pradeep Das. Cryptosporidium related diarrhoea. International Conference on Emerging Infectious Diseases in the Pacific Rim, Bangkok, Thailand, March 2-4, 1999

  6. M. L. Munoz, Gloria Leòn, I. Salazar, J.L. Sanchez Salas, R. Tovar, M. Moreno C. Fiori and Pradeep Das. Attended “federation of American Societies of Experimental Biology” and presented a paper on “The relationship among the cytoskeleton rearrangement, gene expression and electron dense granules, held at New Orleans, U.S.A, April 1997.

  7. Deteccion de genes de expresion temprana inducides en Entamoeba histolytica por colagena tipo 1 y Ca2+. V congreso Latinoamericano de Medicina tropical. IPK, Cuba. March, 1997.

  8. Electron dense granules and the pathogenicity in E. histolytica. International Congress on Amoebiasis, Mexico city, Mexico, 29-31 Jan, 1997.

  9. On invitation from “International Congress on Amoebiasis”, a talk was delivered on “Differential display of messenger RNAs from E. histolytica activated by collagen type I and Ca2+” at CINVESTAV, Mexico City, Mexico, Jan 31, 1997.

  10. Differencial displays of m-RNA from E. histolytica during electron dense granules secretion. International Congress on Amoebiasis, Mexico city, Mexico, 29-31 Jan, 1997.

  11. Purification and characterization of Electron Dense granules containing collagenase activity from E. histolytica. VIII International Congress of Parasitology. IZMIR, Turkey, 1994.

  12. Biochemical and Immunological characterization of plasma membrane antigen(s) of Giardia Lamblia. VII International congress of Parasitology (ICOPA VII), Paris, France, 1990.

  13. Positive regulatory effect of EGF on Synthesis and stability of the EGF receptor American Society of Biological Chemist. Philadelphia, USA, 1988.

  14. Studies on Giardia Lamblia trophozoites antigens using Sephacryl S-300 column chromatography PAGE and ELISA. Calgary Giardia Conference, Canada, 1987.

  15. Purification of excretory secretory antigen of E. histolytica and their role in immunodiagnosis and protection. 7th International Conference of Protozoology, Nairobi, Kenya, 1986.

  16. Role of Excretory secretory antigen of E. histolytica in serodiagnosis of amoebiasis. 3rd Asian Conference on diarrhoeal diseases, Thailand, 1985.
 
Major achievements:
  1. Receptor biology studies, maintenance of primary and secondary, normal and carcinoma cell lines of human, animal and insects origin;

  2. Purification and characterization of receptors from cell lines, immuno-precipitation, radio-iodination of proteins and Ligands etc;

  3. Whole Hybridoma technology viz; production of monoclonal antibodies and use of MAbs in immuno and differential diagnosis of pathogenic to non pathogenic strains, characterization and purification of antigens, characterization of immunodominant epitopes;

  4. Immunological techniques such as Western blotting; CIEP, IHA, GDP, ELISA, IFA, MIF, and DTH reactions, purification of immunoglobulins etc. Techniques used in protein chemistry: Column chromatography (FPLC, HPLC), Isolation, purification and characterization of membrane and cytosolic antigenic proteins from various parasites, SDS PAGE, 2-dimensional gel electrophoresis, substrate gels for proteolytic enzyme analysis etc. development of animal models for human parasites;

  5. Molecular biological techniques viz: Construction of cDNA library, screening of library by antibody and oligos, transfection of genes, Microarray technology, mRNA differential display technology, quantitative and semi quantitative PCR, construction of vector, cloning and sequencing of DNA fragments, genotying and sub-genotyping, expression of recombinant proteins in suitable vectors etc