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Subhankar Kumar Singh
Scientist D
 
Date of Birth:
22-01-1973
Sex: Male
Date of Joining in ICMR: 21st March 2001
Designation: Scientist D
Discipline: Immunology
Date of Joining in Present Post:
01.09.12

Office
Rajendra Memorial Research Institute of Medical Sciences
(Indian Council of Medical Research)Department of Health Research, Ministry of Health & Family Welfare, Govt of India, Agamkuan, Patna-800007
Telephone: 0612- 2631565
Fax: 0612-2634379
Residence: RMRIMS Campus (ICMR)
Agamkuan, Patna-800007
Mobile: 09334115524
E-Mail: sksrmri@yahoo.com
 
Educational Qualifications:
  • Ph.D. (2010)
  • M.Sc. (1995): 1st Div.
  • B. Sc. Hons. (1993): 1st Div.
 
Research Experience:
 
Post Organization Period
Research Assistant
Rajendra Memorial Research Institute of Medical Sciences, Patna. 21.03.2001-30.06.2008
Scientist B

Rajendra Memorial Research Institute of Medical Sciences, Patna. 30.06.2008- 31.08.12
Scientist C

Rajendra Memorial Research Institute of Medical Sciences, Patna. 01-09-2012 To 31-08-2016
Scientist D

Rajendra Memorial Research Institute of Medical Sciences, Patna. 01-09-2016 - till date.
 
Membership/Fellowship:
  • Awarded Fellowship by the Govt. of Switzerland for Advanced Course on Immunology, Vaccinology and Biotechnology Applied to Infectious Diseases (in English) from 4 Sept. to 18 Oct. 2007” organized by UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), WHO, 20 Avenue Appia, CH-1211 Geneva 27, Switzerland at WHO Immunology Research and Training Centre IRTC; Department de Biochimie, University of Lausanne, Switzerland.
 
Awards: 
  • Awarded Fellowship by the Govt. of Switzerland for Advanced Course on Immunology, Vaccinology and Biotechnology Applied to Infectious Diseases (in English) from 4 Sept. to 18 Oct. 2007” organized by UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), WHO, 20 Avenue Appia, CH-1211 Geneva 27, Switzerland at WHO Immunology Research and Training Centre IRTC; Department de Biochimie, University of Lausanne, Switzerland.
 
Foreign Visits:
  • WHO, Geneva and IRTC, Lausanne, Switzerland (2007) as WHO Fellow for Advanced Course on Immunology, Vaccinology and Biotechnology Applied to Infectious Diseases from 4th Sept. to 18th Oct. 2007.

  • Charite – Universitatsmendizin Berlin, Medical School of the Humboldt University and the Free University in Berlin, Germany for training and optimization of protocol for vaccine development project LeishDNAVax under European Union Framework Programme 7 (EU FP7) from 21st to 25th Oct. 2010.
 
Seminars/Symposiums/Workshops/Conference
  • ICMR/WHO/TDR sponsored workshop for investigators of Phase IV Miltefosine for the treatment of Visceral Leishmaniasis on 26th to 28th May 2002 at RMRIMS (ICMR) Agamkuan, Patna-7.

  • Attended National Symposium on Plant Biotechnology: role of sustainable development and 25th Meeting of Plant Tissue Culture Association (India), at University of Rajasthan, HCM, RIPA, Jaipur, February 17-19th 2003.

  • Attended conference of 3rd Convention of Society for Immunology and Immunopathology, 13-15 February 2004 at CJIL, Agra and presented paper “Role of Azadirachta indica A. Juss. antigen in modulation of signal transduction for T-cell activation in VL”.

  • Workshop on “Molecular & Immunological Methods” (PCR, RFLP, RAPD, Microarrays etc.) organized by SIIP on Feb 15th 2004 at CJIL, Agra.

  • Attended 33rd Indian Immunology Society Conference (28th-31st January 2007) on Molecular and clinical immunology in health and disease at Department of Biochemistry, AIIMS, New Delhi-110029, India.

  • Successfully completed Advanced Course on Immunology, Vaccinology and Biotechnology Applied to Infectious Diseases (in English) from 4 Sept. to 18 Oct. 2007” organized by UNICEF/UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Diseases (TDR), WHO, 20 Avenue Appia, CH-1211 Geneva 27, Switzerland at WHO Immunology Research and Training Centre IRTC; Department de Biochimie, University of Lausanne, Switzerland.

  • Attended 10th Indo-US Cytometry Workshop at Institute of Life Sciences, Bhubaneswar from 13th Feb. 2009 to 21st Feb. 2009. Organized by Institute of Life Sciences Bhubaneswar, India and Department of Pathology, Miller School of Medicine, Univ. of Miami, USA.

  • Attended workshop on “Good Clinical Laboratory Practice Training Course” sponsored by UNICEF, UNDP, World Bank, WHO special programme for Research & Training in Tropical Disease (TDR) from 4th to 6th August 2009.

  • Attended the workshop on Preparing/Writing Manuscript in Medical Journals jointly organized by MSF and RMRIMS on 28th October 2009 at RMRIMS, Patna.

  • Attended International symposium on current trends in Pharmaceutical Research on Orphan Disease: Organized by NIPER-Hajipur at Patna, on 10th Jan, 2010.

  • Participated in the BD-RMRIMS Workshop on Basic and Research Applications of Flow Cytometry organized by Rajendra memorial Research Institute of Medical Sciences (ICMR) and Becton Dikinson (BD) India Pvt. Ltd. from 27th April-1st May, 2010 as a Resource Person.

  • Visited Berlin for training and optimization of protocol for vaccine development project LeishDNAVax under European Union Framework Programme 7 (EU FP7) at Charite – Universitatsmendizin Berlin, Medical School of the Humboldt University and the Free University in Berlin, Germany in Oct. 2010.
 
Major achievements:
  • The immunological studies based on evaluation of immunodiagnostic tests as well as studies on cellular mechanism of immunosuppression in VL are the key areas mainly addressed by the investigator. Besides ascertaining value of direct agglutination test (DAT) in serodiagnosis and to identify asymptomatic infection in community, usefulness of other immunodiagnostic tests such as freeze-dried DAT, rK-39, rK26 and KATEX have also been reported by the investigator in a WHO/TDR sponsored project.

  • Visceral Leishmaniasis is a macrophage-associated disorder where, inability of T cells to support macrophage function often results in exacerbation of disease. It was reported by investigator that infection with L. donovani induces less CD2 on the surface of CD4+ T-cells, which once activated orchestrate the protective IFN-g dominant host defense mechanism via PKC-mediated signal transduction and cell proliferation. Many antigens with immunoprophylactic potentials have been identified, particularly 17 and 63kDa. Work was carried out to modulate CD4 cell response in VL patients with certain Leishmania antigens as immunoprophylactic candidate. Besides, at least five components from different plants with pronounced anti-leishmanial effect has been explored. The investigator also explored the immunoprophylactic capabilities of few of these substances through its effect on cell proliferation, activation and effecter function. Presently I am working on Leishmania antigen responsible for regulatory function of Natural T-regulatory cells in VL.