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Publications List of Dr. Ashish Kumar



Kumar P,  Shivam P,  Mandal S,  Prasanna P,  Kumar S,  Prasad SR,  Kumar A,  Das P,  Ali V,  Singh SK,  Mandal D.. Synthesis, characterization, and mechanistic studies of a gold nanoparticle–amphotericin B covalent conjugate with enhanced antileishmanial efficacy and reduced cytotoxicity International Journal of Nanomedicine, 2019, doi.org/10.2147/IJN.S196421



Das S, Kumar A, Mandal A, Abhishek K, Verma S, Kumar A, Das P. Nucleic acid sensing activates the innate cytosolic surveillance pathway and promotes parasite survival in visceral leishmaniasis. Sci Rep. 2019 Jul 8;9(1):9825. doi: 10.1038/s41598-019-45800-0.



Kumar A, Das S, Mandal A, Verma S, Abhishek K, Kumar A, Kumar V, Ghosh AK, Das P. Leishmania infection activates host mTOR for its survival by M2 macrophage polarization. Parasite Immunol. 2018 Nov;40(11):e12586. doi: 10.1111/pim.12586.





Abhishek K, Das S, Kumar A, Kumar A, Kumar V, Saini S, Mandal A, Verma S, Kumar M, Das P. Leishmania donovani induced Unfolded Protein Response delays host cell apoptosis in PERK dependent manner. PLoS Negl Trop Dis. 2018 Jul;12(7):e0006646. doi: 10.1371/journal.pntd.0006646.



Kumar V, Kumar A, Das S, Kumar A, Abhishek K, Verma S, Mandal A, Singh RK, Das P. Leishmania donovani Activates Hypoxia Inducible Factor-1α and miR-210 for Survival in Macrophages by Downregulation of NF-κB Mediated Pro-inflammatory Immune Response. Front Microbiol. 2018; 9:385. doi: 10.3389/fmicb.2018.00385.



Verma S, Mandal A, Ansari MY, Kumar A, Abhishek K, Ghosh AK, Kumar A, Kumar V, Das S, Das P. Leishmania donovani Inhibitor of Serine Peptidases 2 Mediated Inhibition of Lectin Pathway and Upregulation of C5aR Signaling Promote Parasite Survival inside Host. Front Immunol. 2018; 9:63. doi: 10.3389/fimmu.2018.00063.



Mandal A, Das S, Kumar A, Roy S, Verma S, Ghosh AK, Singh R, Abhishek K, Saini S, Sardar AH, Purkait B, Kumar A, Mandal C, Das P. l-Arginine Uptake by Cationic Amino Acid Transporter Promotes Intra-Macrophage Survival of Leishmania donovani by Enhancing Arginase-Mediated Polyamine Synthesis. Front Immunol. 2017; 8:839. doi: 10.3389/fimmu.2017.00839. eCollection 2017.



Mansuri R, Kumar A, Rana S, Panthi B, Ansari MY, Das S, Dikhit MR, Sahoo GC, Das P. In Vitro Evaluation of Antileishmanial Activity of Computationally Screened Compounds against Ascorbate Peroxidase To Combat Amphotericin B Drug Resistance. Antimicrob Agents Chemother. 2017 Jul; 61(7). doi: 10.1128/AAC.02429-16.



Rabi Das VN, Siddiqui NA, Pal B, Lal CS, Verma N, Kumar A, Verma RB, Kumar D, Das P, Pandey K. To evaluate efficacy and safety of amphotericin B in two different doses in the treatment of post kala-azar dermal leishmaniasis (PKDL). PLoS One. 2017; 12(3):e0174497. doi: 10.1371/journal.pone.0174497. eCollection 2017.



Abhishek K, Sardar AH, Das S, Kumar A, Ghosh AK, Singh R, Saini S, Mandal A, Verma S, Kumar A, Purkait B, Dikhit MR, Das P. Phosphorylation of Translation Initiation Factor 2-Alpha in Leishmania donovani under Stress Is Necessary for Parasite Survival. Mol Cell Biol. 2017 Jan 1; 37(1). doi: 10.1128/MCB.00344-16.



Saini S, Kumar Ghosh A, Singh R, Das S, Abhishek K, Kumar A, Verma S, Mandal A, Hasan Sardar A, Purkait B, Kumar A, Kumar Sinha K, Das P. Glucose deprivation induced upregulation of phosphoenolpyruvate carboxykinase modulates virulence in Leishmania donovani. Mol Microbiol. 2016 Dec; 102(6):1020-1042. doi: 10.1111/mmi.13534. Epub 2016 Oct 27.



Das S, Mandal R, Rabidas VN, Verma N, Pandey K, Ghosh AK, Kesari S, Kumar A, Purkait B, Lal CS, Das P. Chronic Arsenic Exposure and Risk of Post Kala-azar Dermal Leishmaniasis Development in India: A Retrospective Cohort Study. PLoS Negl Trop Dis. 2016 Oct; 10(10):e0005060. doi: 10.1371/journal.pntd.0005060. eCollection 2016 Oct.



Dikhit MR, Purkait B, Singh R, Sahoo BR, Kumar A, Kar RK, Ansari MY, Saini S, Abhishek K, Sahoo GC, Das S, Das P. Activity of a novel sulfonamide compound 2-nitro-N-(pyridin-2-ylmethyl)benzenesulfonamide against Leishmania donovani. Drug Des Devel Ther. 2016; 10:1753-61. doi: 10.2147/DDDT.S96650. eCollection 2016.



Singh R, Purkait B, Abhishek K, Saini S, Das S, Verma S, Mandal A, Ghosh AK, Ansari Y, Kumar A, Sardar AH, Kumar A, Parrack P, Das P. Universal minicircle sequence binding protein of Leishmania donovani regulates pathogenicity by controlling expression of cytochrome-b. Cell Biosci. 2016; 6:13. doi: 10.1186/s13578-016-0072-z. eCollection 2016.



Ghosh AK, Sardar AH, Mandal A, Saini S, Abhishek K, Kumar A, Purkait B, Singh R, Das S, Mukhopadhyay R, Roy S, Das P. Metabolic reconfiguration of the central glucose metabolism: a crucial strategy of Leishmania donovani for its survival during oxidative stress. FASEB J. 2015 May; 29(5):2081-98. doi: 10.1096/fj.14-258624. Epub 2015 Feb 17.



Purkait B; Singh R; Wasnik K; Das S; Kumar A; Paine M; Dikhit M; Singh D; Sardar A; Ghosh A; Das P. Up-regulation of Silent Information Regulator 2 (Sir2) is associated with Amphotericin B resistance in clinical isolates of Leishmania donovani. J Antimicrob Chemother, 2015, doi:10.1093



Kumar A, Das S, Purkait B, Sardar AH, Ghosh AK, Dikhit MR, Abhishek K, Das P. Ascorbate peroxidase, a key molecule regulating amphotericin B resistance in clinical isolates of Leishmania donovani. Antimicrob Agents Chemother. 2014 Oct; 58(10):6172-84. doi: 10.1128/AAC.02834-14. Epub 2014 Aug 11.



Sardar AH, Kumar S, Kumar A, Purkait B, Das S, Sen A, Kumar M, Sinha KK, Singh D, Equbal A, Ali V, Das P. Proteome changes associated with Leishmania donovani promastigote adaptation to oxidative and nitrosative stresses. J Proteomics. 2013 Apr 9; 81:185-99. doi: 10.1016/j.jprot.2013.01.011.



Singh D, Pandey K, Das VN, Das S, Verma N, Ranjan A, Lal SC, Topno KR, Singh SK, Verma RB, Kumar A, Sardar AH, Purkait B, Das P. Evaluation of rK-39 strip test using urine for diagnosis of visceral leishmaniasis in an endemic region of India. Am J Trop Med Hyg. 2013 Feb; 88(2):222-6.doi: 10.4269/ajtmh.2012.12-0489



Das S, Pandey K, Kumar A, Sardar AH, Purkait B, Kumar M, Kumar S, Ravidas VN, Roy S, Singh D, Das P. TGF-β1 re-programs TLR4 signaling in L. donovani infection: enhancement of SHP-1 and ubiquitin-editing enzyme A20. Immunol Cell Biol. 2012 Jul; 90(6):640-54. doi: 10.1038/icb.2011.80            



Sardar AH, Das S, AgnihortiS., KumarM., Ghosh AK, Abhishek K., KumarA., PurkaitB., AnsariM. Y.and DasP., Spinigerin induces apoptotic like cell death in a caspase independentmanner in Leishmania donovani. Exp Parasitol. 2013 Dec; 135(4):715-25. doi: 10.1016/j.exppara.2013.10.011.



Kumar A,Purkait B, Nandi N, Sardar AH, Das S, Kumar S, Pandey K, Ravidas V, Kumar M, De T, Singh D, Das P. Mechanism of amphotericin B resistance in clinical isolates of Leishmania donovani. Antimicrob Agents Chemother. 2012 Feb; 56(2):1031-41. doi: 10.1128/AAC.00030-11.



Nandi N, Bera T, Kumar S, Purkait B, Kumar A, Das P. Involvement of thermoplasmaquinone-7 in transplasma membrane electron transport of Entamoeba histolytica trophozoites: a key molecule for future rational chemotherapeutic drug designing.J Bioenerg Biomembr. 2011 Apr; 43(2): 203-15. doi: 10.1007/s10863-011-9347-6.